Three deaths have been reported, according to Paul Dutcher, chief of the Perryton Fire Department.
He said a trailer park was one of the areas hit hardest.
Ochiltree County Sheriff Terry Bouchard told NBC affiliate KAMR of Amarillo that the tornado caused "a lot of damage," particularly to mobile homes and businesses.
Over fifty people were admitted to Perryton's Ochiltree General Hospital, the hospital reported.